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(A) Retrieving the conformational biding of raloxifene with ER-α (PDB 1ERR). (B) Predicted conformational binding of N, N-Diethylamino analog of Raloxifene with ER-α. (C) Molecular structure of CRBN and VHL ligand. (D) VHL-based PROTACs (ERD-308, ERD-148).
