Table 1.
Effects of purified H. scabra compounds on mean lifespans of wildtype N2 worms at 25 °C.
| Compounds | Lifespan (Mean ± SD) | (Number of Worms, Censored) | % Increase Lifespan |
p Value (Log-Rank Test) |
|---|---|---|---|---|
| 1% DMSO | 12.28 ± 1.76 | (145, 8) | - | - |
| 1 μg/mL DEHP | 12.18 ± 1.97 | (137, 2) | −0.81 | 0.9737 |
| 5 μg/mL DEHP | 12.36 ± 2.10 | (145, 4) | 0.65 | 0.2603 |
| 10 μg/mL DEHP | 12.29 ± 2.49 | (129, 2) | 0.08 | 0.2695 |
| 1% DMSO | 12.04 ± 1.91 | (126, 2) | - | - |
| 1 μg/mL 2-BTHF | 12.35 ± 1.86 | (127, 9) | 2.57 | 0.1694 |
| 5 μg/mL 2-BTHF | 12.72 ± 1.90 | (151, 2) | 5.65 | 0.0012 ** |
| 10 μg/mL 2-BTHF | 12.37 ± 2.36 | (142, 3) | 2.74 | 0.0192 * |
| 1% DMSO | 11.10 ± 1.70 | (118, 2) | - | - |
| 1 μg/mL holothuria A | 11.13 ± 1.88 | (121, 2) | 0.27 | 0.5654 |
| 5 μg/mL holothuria A | 11.45 ± 1.79 | (118, 1) | 3.15 | 0.0895 |
| 10 μg/mL holothuria A | 11.44 ± 1.77 | (123, 3) | 3.06 | 0.0703 |
| 1% DMSO | 12.12 ± 2.14 | (123, 0) | - | - |
| 1 μg/mL holothuria B | 12.07 ± 1.91 | (134, 0) | −0.41 | 0.5685 |
| 5 μg/mL holothuria B | 12.17 ± 2.00 | (134, 2) | 0.41 | 0.8980 |
| 10 μg/mL holothuria B | 12.30 ± 1.85 | (112, 1) | 1.49 | 0.8498 |
| 1% DMSO | 11.45 ± 1.87 | (132, 4) | - | - |
| 1 μg/mL palmitic acid | 11.99 ± 1.86 | (148, 2) | 4.72 | 0.0207 * |
| 5 μg/mL palmitic acid | 11.46 ± 1.92 | (127, 0) | 0.09 | 0.8550 |
| 10 μg/mL palmitic acid | 11.48 ± 1.96 | (145, 0) | 0.26 | 0.8037 |
* and ** Indicates significant increase in mean lifespan between the treated group and the control group at p < 0.05 and p < 0.01.