Table 5.
Number of electrostatic and hydrophobic interactions between natriuretic receptors and their ligands (L2 and BNP).
| hNPR-A | hNPR-B | hNPR-C | |||||
|---|---|---|---|---|---|---|---|
| Type of Interaction | Monomer 1 | Monomer 2 | Monomer 1 | Monomer 2 | Monomer 1 | Monomer 2 | |
| L2 | Electrostatic | 5 | 5 | 8 | 8 | 7 | 6 |
| Hydrophobic aromatic | 1 | 2 | 1 | 1 | 1 | 2 | |
| Hydrophobic non aromatic | 4 | 5 | 5 | 1 | 3 | 4 | |
| BNP | Electrostatic | 9 | 9 | 18 | 8 | 10 | 3 |
| Hydrophobic aromatic | - | - | - | - | 1 | - | |
| Hydrophobic non aromatic | 12 | 5 | 3 | 6 | 1 | 4 | |
Electrostatic and hydrophobic interactions between the two natriuretic receptor monomers and L2 and BNP were determined using Protein Structure and Interaction Analyzer (PSAIA) at 4.5 Å. BNP, B-type natriuretic peptide; L2, Lebetin 2; NPR, Natriuretic peptide receptor; hNPR-A, human natriuretic peptide receptor A; hNPR-B, human natriuretic peptide receptor B; hNPR-C, human natriuretic peptide receptor C.