FIG. 3.

Effect of gene transfer of LL-37/hCAP-18 to the respiratory tracts of mice on the bacterial load and inflammatory response. Mice were injected intratracheally on day 1, challenged with bacteria on day 5, and euthanized on day 6. Individual data points are presented. The bar represents the mean. (A) The bacterial load was significantly decreased in mice that received the LL-37/hCAP-18-encoding vector (Ad.LL-37) (P < 0.005). (B) Levels of TNF-α were significantly lower in mice that received the LL-37/hCAP-18-encoding vector (P < 0.05) (40 mice per group).