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. 2022 Nov 25;8(47):eade6844. doi: 10.1126/sciadv.ade6844

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Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 5. — PBMCs were collected from three EBV-seronegative healthy females (EBV⁻ HD, black circles), four EBV-seropositive healthy females (EBV⁺ HD, green triangles), and five females with RRMS that are all EBV seropositive (EBV⁺ MS, orange diamonds). PBMCs were processed for flow cytometry immediately following isolation. (A) Representative gating strategy for ABCs (CD19⁺CD20⁺CD11c⁺CD21⁻) from human PBMCs. (B) Proportion of ABCs (CD11c⁺CD21⁻) among previously activated B cells (CD19⁺CD20⁺IgD⁻). (C to E) Representative samples and percent of ABCs (CD19⁺CD20⁺CD11c⁺CD21⁻) positive for (C) Fas, (D) PD1, and (E) CD27. Data for CD27- and PD1-stained samples are fewer (n = 2 to 4 donors per group) due to later addition of these markers following initial findings. Data are presented as means ± SEM, analyzed by one-way ANOVA with multiple comparisons; **P < 0.01 and *P < 0.05.