Fig. 7. Conceptual model of a translational device to deliver cytostatic hypothermia for GBM.

Representative diagram of a patient with GBM implanted with an envisioned cytostatic hypothermia system with zoomed inset of device (right). The envisioned system consists of an intracranial device consisting of a multiprobe array in conjunction with a cooling Peltier plate and a water block. An implanted, nonlocal, nonmagnetic pump facilitates water flow through tunneled, subcutaneous tubing to carry heat away from the hot side of the Peltier plate and distribute it to the surrounding skin via the tubing and a subcutaneous heat sink. Inset shows a slice of the cranial cavity after tumor resection with a hypothetical cytostatic hypothermia device and the remaining nonresectable tumor cells. A multiprobe array is envisioned to facilitate homogeneous cooling at the site of possible tumor recurrence.