Table 2. Eisenberg hydrophobicity scores (Eisenberg et al., 1982) of the pore facing residues of human GSDMD and mouse GSDMA3 in kcal mol^-1.

Structural element	human GSDMD		mouse GSDMA3
	Pore facing residues	ΣEisenberg hydrophobicity	Pore facing residues	ΣEisenberg hydrophobicity
β3	ADQQSE	–2.73	MDQQLE	–1.93
β5	KAGASS	–0.96	TKKTGS	–2.66
β7	TKESRS	–4.18	TNNISP	–1.06
β8	QEQHSK	–3.76	LGQSNN	–1.54
Σfull sheet		–11.63		–7.19