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. 2022 Nov 23;86:104371. doi: 10.1016/j.ebiom.2022.104371

Fig. 7.

Fig. 7

Characterization of predicted T-macrophage/DC interactions in pre- and post-neoCRT ESCCs. (a) Differences in the number of significant interactions between intermediate activated/exhausted CD8+ T and subtypes of macrophages and DCs in pre- and post-neoCRT ESCCs. ∗, P < 0.05; NS, not significant by Wilcoxon signed-rank test. (b) Bar plot showing the proportions of significant interacting pairs between intermediate activated/exhausted CD8+ T cells and subtypes of macrophages and DCs with increased, decreased, or unchanged percentages after neoCRT. Ligand (red) and receptor (blue) cells are shown on the x-axis. (c, d) Dot plot showing the top 50 (c) and 45 (d) interacting ligand–receptor pairs between intermediate activated/exhausted CD8+ T and subtypes of macrophages (c) and cDCs (d) with decreased percentages after neoCRT. Cell subtypes are shown on the x-axis; ligand (red) and receptor (blue) pairs are shown on the y-axis. The color of the circle denotes the percentages of samples with a significant interaction (P < 0.05 by CellphoneDB which uses a one-side permutation test to compute significant interactions) in the total samples with these interacting cell subsets. AE, intermediate activated/exhausted; M, macrophage.