Table 2.
A Summary of Several Studies on Lp(a) Cutoff Values in Chinese Populations
Population | Sample Size | Primary Endpoint | High Lp(a) vs Low Lp(a) | Main Conclusions | Lp(a) Cutoff |
---|---|---|---|---|---|
Healthy population receiving routine physical checkup16 | 9,238 | Myocardial infarction | Lp(a) <16.7 mg/dL vs Lp(a) ≥16.7 mg/dL | High Lp(a) is significantly correlated with myocardial infarction | 17 mg/dL |
Patients with a history of CAD37 | 7,562 | Recurrent CVE | The first tertile of Lp(a) levels (<8.88 mg/dL) vs the third tertile (≥26.45 mg/dL) | High Lp(a) is independently correlated with the risk of recurrent CVE | 26.45 mg/dL |
Stable CAD patients with a history of PCI43 | 4,078 | CVE | Lp(a) <15 mg/dL vs Lp(a) ≥30 mg/dL | High Lp(a) is correlated with CVE | 30 mg/dL |
Patients with a history of MI45 | 3,864 | CVE | The first quartile of Lp(a) levels (<8.19 mg/dL) vs the third quartile (18.84-41.43 mg/dL) | The cumulative rates of CVEs and cardiac mortality were significantly higher in patients with high Lp(a) levels | 18.84 mg/dL |
Population aged >40 y and receiving routine physical check-up26 | 8,500 | Stroke | Lp(a) <26 mg/dL vs Lp(a) ≥26 mg/dL | High Lp(a) is significantly correlated with stroke | 26 mg/dL |
Patients with ischemic stroke (ischemic and hemorrhagic)38 | 2,149 | Stroke | The first quartile of Lp(a) levels (<4.6 mg/dL) vs the fourth quartile (≥23.2 mg/dL) | High Lp(a) is positively correlated with ischemic and hemorrhagic ischemic stroke | 23.2 mg/L |
CVE = cardiovascular event; MI = myocardial infarction; PCI = percutaneous coronary intervention; other abbreviations as in Table 1.