Table 1.
Clinical Characteristics Over Time
| 2007 (n = 2,096) | 2008 (n = 1,832) | 2009 (n = 2,094) | 2010 (n = 2,744) | 2011 (n = 2,809) | 2012 (n = 3,192) | 2013 (n = 3,440) | 2014 (n = 4,080) | 2015 (n = 4,079) | 2016 (n = 4,187) | P Value | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Demographics | |||||||||||
| Age, y | 69 (60-78) | 68 (59-77) | 69 (60-78) | 69 (60-78) | 69 (60-78) | 69 (59-79) | 69 (59-78) | 69 (59-79) | 69 (59-78) | 69 (59-79) | 0.035 |
| Male | 1,539 (73.4) | 1,367 (74.6) | 1,558 (74.4) | 2,087 (76.1) | 2,135 (76.0) | 2,335 (73.2) | 2,609 (75.8) | 3,088 (75.7) | 3,122 (76.5) | 3,180 (76.0) | 0.009 |
| BMI, kg/m2 | Not available | Not available | 23.4 (21.2-25.5) | 23.4 (21.3-25.8) | 23.5 (21.3-26.0) | 23.5 (21.1-25.9) | 23.5 (21.3-26.0) | 23.4 (21.2-25.9) | 23.4 (21.2-26.0) | 23.5 (21.3-26.0) | 0.736 |
| STEMI | 1,602 (76.4) | 1,450 (79.1) | 1,428 (68.2) | 1,856 (67.6) | 1,975 (70.3) | 2,234 (70.0) | 2,561 (74.4) | 3,012 (73.8) | 3,134 (76.8) | 3,129 (74.7) | <0.001 |
| Risk factor | |||||||||||
| Hypertension | Not available | Not available | 949 (45.3) | 1,581 (57.6) | 1,652 (58.8) | 1,813 (56.8) | 2,069 (60.1) | 2,353 (57.7) | 2,484 (60.9) | 2,521 (60.2) | <0.001 |
| Diabetes mellitus | Not available | Not available | 494 (23.6) | 865 (31.5) | 899 (32.0) | 973 (30.5) | 1,043 (30.3) | 1,241 (30.4) | 1,294 (31.7) | 1,304 (31.1) | <0.001 |
| Dyslipidemia | Not available | Not available | 654 (31.2) | 1,119 (40.8) | 1,259 (44.8) | 1,279 (40.1) | 1,386 (40.3) | 1,633 (40.0) | 1,726 (42.3) | 1,780 (42.5) | <0.001 |
| Current smoker | Not available | Not available | Not available | Not available | Not available | Not available | 774 (24.0) | 1,134 (27.9) | 1,204 (29.5) | 1,185 (28.3) | <0.001 |
| Hyperuricemia | Not available | Not available | 103 (4.9) | 97 (3.5) | 129 (4.6) | 164 (5.1) | 183 (5.3) | 206 (5.0) | 240 (5.9) | 269 (6.4) | <0.001 |
| Cardiovascular and renal disease | |||||||||||
| Previous MI | Not available | Not available | 135 (6.4) | 241 (8.8) | 259 (9.2) | 274 (8.6) | 293 (8.5) | 338 (8.2) | 328 (8.0) | 298 (7.1) | 0.238 |
| Previous PCI | Not available | Not available | 105 (5.0) | 241 (8.8) | 273 (9.7) | 278 (8.7) | 334 (9.7) | 410 (10.0) | 425 (10.4) | 373 (8.9) | <0.001 |
| Previous CABG | Not available | Not available | 23 (1.1) | 50 (1.8) | 50 (1.8) | 44 (1.4) | 50 (1.5) | 63 (1.5) | 48 (1.2) | 80 (1.9) | 0.612 |
| Previous CHF | Not available | Not available | 28 (1.3) | 51 (1.9) | 38 (1.4) | 70 (2.2) | 57 (1.7) | 99 (2.4) | 79 (1.9) | 75 (1.8) | 0.091 |
| Previous stroke | Not available | Not available | 88 (4.2) | 142 (5.2) | 174 (6.2) | 177 (5.5) | 225 (6.5) | 247 (6.1) | 274 (6.7) | 254 (6.1) | <0.001 |
| Previous PAD | Not available | Not available | 32 (1.5) | 82 (3.0) | 73 (2.6) | 99 (3.1) | 79 (2.3) | 118 (2.9) | 97 (2.4) | 135 (3.2) | 0.050 |
| Hemodialysis | Not available | Not available | 22 (1.1) | 34 (1.2) | 43 (1.5) | 54 (1.7) | 50 (1.5) | 67 (1.6) | 53 (1.3) | 71 (1.7) | 0.136 |
| Killip classification | |||||||||||
| n | 1,724 | 1,550 | 1,753 | 2,382 | 2,448 | 2,960 | 3,293 | 3,954 | 4,011 | 4,140 | |
| I | 1,237 (71.8) | 1,138 (73.4) | 1,315 (75.0) | 1,741 (73.1) | 1,844 (75.3) | 2,180 (73.6) | 2,446 (74.3) | 2,891 (73.1) | 2,957 (73.7) | 2,999 (72.4) | 0.598 |
| II | 213 (12.4) | 191 (12.3) | 200 (11.4) | 307 (12.9) | 264 (10.8) | 391 (13.2) | 390 (11.8) | 488 (12.3) | 470 (11.7) | 498 (12.0) | 0.734 |
| III | 113 (6.6) | 108 (7.0) | 83 (4.7) | 151 (6.3) | 162 (6.6) | 138 (4.7) | 205 (6.2) | 221 (5.6) | 179 (4.5) | 207 (5.0) | <0.001 |
| IV | 161 (9.3) | 113 (7.3) | 155 (8.8) | 183 (7.7) | 178 (7.3) | 251 (8.5) | 252 (7.7) | 354 (9.0) | 405 (10.1) | 436 (10.5) | <0.001 |
Values are median (IQR) or n (%). P values were tested by Jonckheere-Terpstra trend test for continuous data and Cochran-Armitage trend test for categorical data.
BMI = body mass index; CABG = coronary artery bypass graft; CHF = congestive heart failure; MI = myocardial infarction; PAD = peripheral artery disease; PCI = percutaneous coronary intervention; STEMI = ST-segment elevation myocardial infarction.