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. 2022 Sep 16;18(4):849–855. doi: 10.4103/1673-5374.353495

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Copyright: © Neural Regeneration Research

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CypD deficiency and CsA treatment protect the CST and alleviate motor dysfunction after ICH.

(A) Diagram of retrograde tracking of the CST (left) and GFP-positive corticospinal neurons (right, Bregma: –0.7 mm) in each group. The number of retrograde labeled GFP-positive corticospinal neurons in the ICH^CypD–/– and ICH^WT + CsA groups was greater than that in the ICH^WT group. Scale bar: 100 μm. (B) Number of labeled corticospinal neurons in each group. (C, D) The slip ratio of the contralateral limbs in beam walking (C) and ladder rung walking (D) at 3 days post-ICH in each group. Data are shown as the mean ± SEM (n = 6–8 animals for each group). *P < 0.05, **P < 0.01, ***P < 0.001, vs. ICH^WT group (one-way analysis of variance followed by Tukey’s post hoc test). CsA: Cyclosporin A; CST: corticospinal tract; CypD: cyclophilin D; GFP: green fluorescent protein; ICH: intracerebral hemorrhage; WT: wild type.