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. 2022 Sep 16;18(4):760–762. doi: 10.4103/1673-5374.353480

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The different mechanisms by which melatonin may improve MSCs-based cell transplantation.

The upper part of the figure shows the main effects stimulated by melatonin and responsible for the reduction of apoptosis and senescence, as shown in the lower part of the figure. The improved mitochondrial functions and trafficking via TNTs may represent the key mechanisms by which melatonin may improve MSCs cell transplantation and organ functions. MSCs: Mesenchymal stem cells; PrPc: cellular prion protein; SIRT3: Sirtuin 3; TIM23: translocase of inner membrane 23; TNTs: tunneling nanotubes; TOM20: translocase of outer membrane 20; VEGF: vascular endothelial growth factor. Created with BioRender.com.