Table 2.

Duration of antimicrobial therapy for CIED infection when the device can be removed

Extent of infection	Duration∗
Pocket site†,‡	7–14 d17,28,35
Pocket-site infection	10–14 d
CIED erosion through skin without obvious purulence	7–10 d
Blood cultures positive§
Valve vegetation‖	4–6 wk47
Lead vegetation:
Uncomplicated	as for TEE-negative28
Complicated (eg, septic phlebitis, osteomyelitis)	4–6 wk28
TEE-negative:
Staphylococcus aureus	4 wk28,35
non-S. aureus	2 wk28,35

CIED, cardiovascular implantable electronic device; TEE, transesophageal echocardiogram.

^∗Duration is counted from the date of device explantation or (for those with bacteremia) the date blood cultures became negative, which ever occurred last.³⁵

^†Provided blood cultures collected prior to administration of antibiotics were negative.

^‡Treatment can be changed from intravenous to an active oral antibiotic once susceptibility results are available and the infected CIED has been removed.²⁸

^§Blood cultures positive or no blood cultures performed prior to administration of antibiotics.

^‖Treatment as for endocarditis.^28,35,47