Figure 1.

Trametinib Treatment Promotes Changes in Survival and Routine Health Measurements

(A) Comparison of survival curves demonstrated a statistically significant reduction in survival (69.4 days) in trametinib-treated animals (n = 15-20/group). (B) Trametinib-treated animals experienced a significant weight reduction following long-term treatment. Data were analyzed using a 2-way analysis of variance with a Bonferroni test (n = 10/group). (C) Complete blood counts were procured and normalized to vehicle control (n = 5/group). Data were analyzed using unpaired Student’s t-tests. Data are represented as mean fold change. Bas = basophils; Eos = eosinophils; Hb = hemoglobin; Hct = hematocrit; Lym = lymphocytes; MCH = mean corpuscular hemoglobin; MCHC = mean corpuscular hemoglobin concentration; MCV = mean corpuscular volume; Mon = monocytes; MPV = mean platelet volume; Neu = neutrophils; Plt = platelets; RBC = red blood cells; Tx = treatment; WBC = white blood cells.