Central Illustration.

Prevalence, Predictors, and Prognostic Significance of Low QRS Voltages in Cardiac Amyloidosis

Low QRS voltages (LQRSV) are more frequent in light chain cardiac amyloidosis (AL CA) than in transthyretin cardiac amyloidosis (ATTR CA) and are more commonly identified in younger patients with AL CA with a higher New York Heart Association functional class, natriuretic peptides, advanced left ventricular (LV) remodeling and systolic right ventricular (RV) and LV dysfunction or in patients with ATTR CA with atrial fibrillation, pericardial effusion, lower LV mass, and systolic RV dysfunction. Moreover, LQRSVs are a significant risk factor for cardiovascular mortality in both AL- and ATTR CA. NYHA = New York Heart Association; RV = right ventricular; AL = light chain amyloidosis; ATTR = transthyretin amyloidosis; LQRSV = low QRS voltages.