Table 3.

Analysis of Predictors of CV Mortality in AL CA and ATTR CA

	Univariable Analysis			Multivariable Analysis
	HR	95% CI	P Value	HR	95% CI	P Value
AL CA
Age, y	1.028	0.991-1.067	0.13	1.055	0.995-1.16	0.16
NYHA functional class	6.291	2.881-13.735	<0.001	3.216	3.564-30.938	0.013
GFR, mL/min	1.004	0.990-1.018	0.59
NT-proBNP >1,800/BNP >400a	6.875	2.088-22.639	0.002
Peripheral low QRS voltages	3.143	1.414-6.982	0.005	1.759	2.411-10.176	0.031
Anterior pseudoinfarction	1.545	0.780-3.061	0.21
LA diameter, mm	1.007	0.967-1.047	0.75
IVSd, mm	1.237	1.082-1.413	0.002	1.35	1.284-2.382	0.040
PWTd, mm	1.098	0.978-1.234	0.11	0.78	0.355-0.765	0.045
LVEDD, mm	0.938	0.879-1.001	0.052
RWT	8.823	1.244-62.581	0.029
LVMi, g/m2	1.006	0.999-1.013	0.11	1.006	0.971-1.021	0.47
Total voltage-to-mass ratio	0.027	0.001-0.987	0.049
Pericardial effusion	1.433	0.690-2.974	0.33
LVEF, %	0.970	0.941-1.000	0.051
E/e’	1.051	1.013-1.091	0.008
TAPSE, mm	0.900	0.818-0.989	0.029
sPAP, mm Hg	1.042	1.009-1.076	0.013
ATTR CA
Age, y	1.003	0.964-1.044	0.88	0.965	0.941-1.194	0.63
NYHA functional class	3.709	1.929-7.129	<0.001	1.65	2.401-294.712	0.038
GFR, mL/min	0.988	0.965-1.012	0.34
NT-proBNP >3,000/BNP >250a	6.539	2.460-17.376	<0.001
NAC ATTR staging	4.150	2.441-7.054	<0.001	6.945	5.145-150.918	0.006
Peripheral low QRS voltages	2.605	1.230-5.516	0.012	2.643	1.815-20.166	0.005
Anterior pseudonecrosis	0.965	0.410-2.272	0.94	0.414	0.001-2.377	0.21
LA diameter, mm	1.059	1.004-1.118	0.041	0.969	0.941-1.038	0.34
IVSd, mm	1.000	0.901-1.109	0.99	0.968	0.006-0.694	0.08
PWTd, mm	1.030	0.915-1.159	0.62
LVEDD, mm	1.010	0.948-1.077	0.75
RWT	1.399	0.194-10.077	0.74
LVMi, g/m2	1.002	0.996-1.007	0.61
Total voltage-to-mass ratio	0.010	0.001-1.977	0.088
Pericardial effusion	1.951	0.861-4.423	0.11
LVEF, %	0.960	0.930-0.992	0.01
E/e’	1.031	0.986-1.078	0.17
TAPSE, mm	0.905	0.824-0.994	0.04
sPAP, mm Hg	1.016	0.987-1.047	0.28

Variables with nonzero coefficients in the penalized Cox proportional hazard model used to estimate CIs for the multivariable model.

Abbreviations as in Table 1.

^aNT-proBNP and BNP in ng/L.