Table 3.

Linear-Mixed Effects Model Results of VO_2peak Postchemotherapy, Postintervention, and 1 Year Postintervention

	Postchemotherapy	Postintervention	1-Year Postintervention	Between-Group Difference Postchemotherapy		Between-Group Difference Postintervention		Between-Group Difference 1-Year Postintervention
	LSM ± SE	LSM ± SE	LSM ± SE	LSM Difference (95% CI)	P Value	LSM difference (95% CI)	P Value	LSM difference (95% CI)	P Value
All
Group A	26.3 ± 1.4	29.3 ± 1.5	29.5 ± 1.5	3.1 (2.2 to 4.0)	<0.001	−0.3 (−1.3 to 0.8)	0.64	0.5 (−0.7 to 1.7)	0.43
Group B	22.7 ± 1.4	29.1 ± 1.5	28.7 ± 1.5
Testicular
Group A	31.9 ± 1.0	36.2 ± 1.2	37.5 ± 1.2	4.4 (2.7 to 6.1)	<0.001	−1.3 (−3.3 to 0.7)	0.19	0.5 (−1.8 to 2.7)	0.68
Group B	28.4 ± 1.0	38.5 ± 1.2	38.0 ± 1.2
Breast
Group A	25.0 ± 0.9	27.6 ± 1.0	27.3 ± 1.0	2.2 (1.1 to 3.3)	<0.001	0.0 (−1.2 to 1.2)	1.00	0.5 (−0.9 to 1.8)	0.52
Group B	20.5 ± 0.9	25.2 ± 1.0	24.5 ± 1.0
Colon
Group A	23.4 ± 1.7	24.7 ± 1.9	22.9 ± 1.8	3.5 (1.2 to 5.7)	0.004	1.4 (−2.0 to 4.8)	0.40	−1.1 (−4.6 to 2.5)	0.53
Group B	23.4 ± 1.3	26.7 ± 1.6	27.4 ± 1.5

P value for mixed-model between-group measures comparing changes in groups A and B from baseline to postchemotherapy, postintervention, and 1 year postintervention, adjusted for baseline values, diagnosis, and center (adjusted baseline values: all patients, 30.8; testicular cancer, 37.6; breast cancer, 27.4; colon cancer, 24.0). The LSMs are estimates extracted from the linear mixed-effects models, which means that these are adjusted for the baseline value, center and diagnosis. In group A, exercise intervention was initiated during chemotherapy; in group B, exercise intervention was initiated after chemotherapy.

LSM = least squares mean.