Table 3.
Multivariate analysis result with lasso regression in the discovery cohort and model specifications.
| Factor | Gene | Origin | Beta | p-value |
|---|---|---|---|---|
| Total bilirubin | – | Recipient | 0.001 | 0.005 |
| rs776746 | CYP3A5 | Donor | 0.313 | <0.001 |
| rs776746 | CYP3A5 | Recipient | 0.352 | <0.001 |
| rs3748930 | CHST10 | Recipient | 0.126 | 0.013 |
| rs4149015 | SLCO1B1 | Recipient | 0.165 | 0.032 |
| Weight | – | Recipient | 0.491 | 0.043 |
The unit of weight is the kilogram. The unit of total bilirubin is umol/L. The genetic features were coded as 0 = AA, 1 = AG, 2 = GG or 0 = CC, 1 = CG, 2 = GG. p < 0.05 was considered as statistically significant.