Table 5.
Odds of CRS (grade 3 to 5 vs 0 to 2) in B-ALL (n = 139)
| Variable (risk group vs ref) | Univariate |
Multivariable |
||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Age (continuous, y) | 1.13 (1.06-1.21) | <.001 | 1.15 (1.07-1.23) | <.001 |
| ≥18 y (adult) vs <18 y (pediatric) | 4.94 (1.90-12.8) | .001 | — | — |
| Sex (male vs female) | 1.40 (0.52-3.82) | .51 | — | — |
| Race/ethnicity (Hispanic vs White NH) | 3.24 (1.23-8.54) | .02 | 4.51 (1.46-13.9) | .001 |
| Other non-Hispanic vs White NH | 1.68 (0.46-6.08) | .43 | 2.0 (0.48-8.41) | .34 |
| Prior allo-HSCT (yes vs no) | 0.38 (0.16-0.93) | .04 | — | — |
| Prior CART (yes vs no) | 0.42 (0.16-1.13) | .08 | — | — |
| Disease burden (M2/3 vs M1) | 4.61 (1.30-16.3) | .02 | 5.48 (1.40-21.5) | .01 |
| BMI (O/O vs non-O/O) | 0.92 (0.35-2.40) | .86 | — | — |
| Obese vs nonobese | 2.1 (0.72-6.1) | .18 | — | — |
| CAR (CD22 vs CD19) | 0.93 (0.36-2.4) | .88 | — | — |
| CD19/22 vs CD19 | 1.30 (0.35-4.90) | .7 | — | — |
Association of patient, treatment, and disease characteristics with CRS severity. Univariate and multivariable ORs were calculated using logistic regression models. The significance of the ‘bold’ font is to signify those which have a significant p-value. The “dash” indicates that the particular variable that it was associated with was not carried forward to the multivariable analysis.