Table 4.
Cumulative Incidence and Time Course of the Six Tumor Kinetic Patterns in Study Cohort
| Pattern I: Stable (N = 401) | Pattern II: Early increase in tumor volume (N = 40) | Pattern III: Later increase in tumor volume (N = 12) | Pattern IV: Early increase in tumor volume followed by stability (N = 6) | Pattern V: Stability followed by increase in tumor volume (N = 1) | Pattern VI: Decrease in tumor volume (N = 23) | |
|---|---|---|---|---|---|---|
| Age at diagnosis (years) | ||||||
| Median | 53 | 47 | 45 | 50 | 50 | 55 |
| Mean, SD | 53, ±15 | 49, ±15 | 46, ±8 | 54, ±20 | NA | 53, ±16 |
| Range | 21–87 | 20–89 | 31–59 | 31–77 | NA | 27–82 |
| 5-Year cumulative incidence % [CI] | 78.8 [74.1–83.5] | 10.0 [6.9–13.1] | 4.1 [1.14–6.8] | 1.9 [0.3–3.5] | 0.6 [0.0–1.8] | 5.6 [2.7–8.5] |
| Duration of active surveillance (years)a | ||||||
| Median | 3.4 | 3.5 | 6.4 | 5.6 | 5.4 | 4.9 |
| Mean, SD | 3.9, ±2.3 | 3.9, ±2.5 | 6.8, ±1.7 | 5.0, ±2 | NA | 5.0, ±3.3 |
| Range | 0.5–14.3 | 0.8–14.0 | 4.8–11.0 | 1.7–7.1 | NA | 1.2–17.0 |
| Time to increase or decrease in tumor volume (years)a | ||||||
| Median | NA | 1.5 | 3.0 | 1.6 | 4.7 | 4.1 |
| Mean, SD | NA | 1.7, ±1.1 | 3.3, ±1.8 | 2.1, ±1.1 | NA | 3.8, ±1.8 |
| Range | NA | (0.3–5.3) | (0.5–7.2) | (1–3.4) | NA | (1.2–6.4) |
| TVDT during exponential growth phase (years) | ||||||
| Median | NA | 2.4 | 7.1 | 3.3 | 0.7 | NA |
| Mean, SD | NA | 2.4, ±1.2 | 10.1, ±9 | 3.2, ±1.4 | NA | NA |
| Range | NA | 1–5 | 5.2–37 | 1.6–4.5 | NA | NA |
a
ANOVA, p < 0.01.
ANOVA, analysis of variance; CI, confidence interval; NA, not applicable.