Table 3.

In silico Pharmacokinetic Analysis: Absorption, Distribution, Metabolism, Excretion and Toxicity of FA2 and Acarbose

Properties	Compounds	Acarbose	FA2
Absorption	Water solubility	Soluble	Moderate
	P-glycoprotein substrate	No	No
	Log Kp (skin permeation) cm/s	-16.29	-6.40
	Blood-Brain Barrier	No	No
	Gastro- Intestinal Absorption	Low	High
Distribution	Subcellular localization	Mitochondria	Mitochondria
Metabolism	CYP 3A2 Inhibitor	No	No
	CYP 2C9 Inhibitor	No	Yes
	CYP 2D6 Inhibitor	No	No
	CYP 2C19 Inhibitor	No	Yes
	CYP 3A4 Inhibitor	No	No
Excretion	Renal OCT2 substrate	No	No
Toxicity	Rat acute toxicity (LD50,mol/kg)	1.46	2.515
	Oral Toxicity classification	VI	III
	Ames toxicity	No	No