The receiver operating characteristic (ROC) curves of the receptor targets and the corresponding reaction type (A) CATK (addition to aldehyde), (B) PAPAIN (ring opening), (C) ALDH3A1 (addition to ketone), (D) CASP3 (addition to ketone), (E) EGFR (Michael addition), (F) JAK3 (Michael addition), (G) CATK (addition to nitrile) and (H) CATS (addition to nitrile). (I) Summary of the AUC value for each of the ROC curve.