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. 2022 Oct 21;41(48):5186–5198. doi: 10.1038/s41388-022-02507-3

Fig. 6. Hypothetical model for the functional interplay of OTUB1 with Hippo signaling in gastric cancer cells.

Fig. 6

OTUB1 associates with YAP, promotes YAP K48-linked ubiquitination and degradation in gastric cancer cells, which promotes the activation of Hippo/YAP axis and gastric cancer progression.