Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 28;220(2):e20211390. doi: 10.1084/jem.20211390

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Nielsen et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Figure S3. — Notch4*^tetEC mice with endothelial deletion of Rbpj from P21 gained less body weight, but both cohorts experienced similar incidence of GI abnormalities. (A) By P77, Notch4*^tetEC mice with endothelial deletion of Rbpj from P21 (Tie2-tTA;TRE-Notch4*;Cdh5-CreER^T2;Rbpj^flox/flox) gained less body weight than mice with Rbpj deletion alone (Tie2-tTA;Cdh5-CreER^T2;Rbpj^flox/flox). ****P < 0.0001, **P = 0.001. (B) GI abnormalities were present at similar incidence in both Tie2-tTA;TRE-Notch4*;Cdh5-CreER^T2;Rbpj^flox/flox and Tie2-tTA;Cdh5-CreER^T2;Rbpj^flox/flox (control) mice. 13 independently repeated experiments. (C) One Tie2-tTA;TRE-Notch4* mouse out of eight after P120 tet off/Notch4* ON was moribund at P138 with hemorrhage, particularly in cerebellum, but no obvious AVM. Scale bar: 2 mm.