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(a) Thiol-functionalized dECM, DTT, PEGαMA, and RGD were reacted through base-catalyzed Michael addition to form soft hydrogel. LAP incubation and exposure to UV light (365 nm) induced hydrogel stiffening. (b) Healthy dECM was incorporated into 18.5 wt% hydrogels at various dECM to DTT ratios (N = 3). (c) Elastic moduli of healthy and fibrotic dECM hybrid-hydrogel, before and after stiffening (N = 9–10).
