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. 2022 Apr 1;30(6):2505–2520. doi: 10.1007/s10787-022-00973-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Effect of DAPA alone or in combination with DORSO or EX-527 on OVX/D-Gal-induced histopathological alterations as well as AD hallmarks (p-Tau and BACE1). a Representative H&E photomicrographs, b illustrative Nissl-stained photomicrographs, and c photomicrographs of p-Tau immuno-histochemical expression. Magnifications: ×400. Bar charts representing d intact neurons and e p-Tau positive cells as well as f BACE1 content in hippocampi of each group where each bar with vertical line illustrating the mean ± SD (n = 3–6). *vs. SO, ^@vs. OVX/D-Gal, ^#vs. DAPA, ^βvs. DAPA + DORSO (one-way ANOVA followed by Tukey’s post hoc test, P < 0.05)