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. 2022 Aug 10;42(8):1748–1765. doi: 10.1007/s10875-022-01312-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Clinical and immunological disease progression of WHIM syndrome. A Cumulative percentage of WHIM syndrome-related manifestations at a given age in all WHIM syndrome patients (n = 66, left panel) and patients prospectively diagnosed patients based on positive family history and < 1 year of age (n = 9, right panel). B Longitudinal analysis of WBC, ANC, and ALC counts (n = 35). Black line represents median value at a given age, dots represent individual patient’s values at a given time point and dotted line is age matched reference values