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. 2022 Aug 1;48(1):240–242. doi: 10.1038/s41386-022-01395-1

Fig. 1. Synaptic plasticity between mPFC interneurons and their long-range afferents is positioned to exert dynamic control of cognition-supporting functional connectivity.

Fig. 1

A Heavily simplified schematic of canonical connections between rodent vHPC inputs and mPFC microcircuits. Highlighted in yellow are neuronal elements (non-specific vHPC inputs [1], SST-INs [2] and VIP-INs [3]) that have been implicated in cognition-supporting oscillatory synchrony and neuronal communication between the vHPC and mPFC. B Long-range functional connectivity between the vHPC and mPFC following manipulations of prefrontal SST-IN activity and vHPC input-SST + interneuron synaptic efficacy. Phase locking of mPFC neuron spiking to vHPC theta oscillations, a measure of vHPC-mPFC theta synchrony, during performance of a spatial working memory task (left) [1]. Optogenetic inhibition of mPFC SST-INs impairs vHPC-mPFC theta synchrony and spatial working memory task performance (middle) [2]. How synaptic potentiation at vHPC synapses onto mPFC SST-INs impacts vHPC-mPFC synchrony and spatial working memory task performance is an important question for future research (right). Created with BioRender.com.