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. 2022 Nov 24;13:7228. doi: 10.1038/s41467-022-35033-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Pharmacokinetic profiles of the (a) prodrugs, (b) released DTX, and (c) total equivalent DTX. All data of a–c were presented as mean ± SD (n = 3 rats). Source data are provided as a Source Data file. d Biodistribution of DiR-solution or DiR-labeled HPNAs. Quantitative analysis of biodistribution at 4 h (e) and 12 h (f). g The accumulated DTX of Taxotere and HPNAs in tumor. All data of e–g were presented as mean ± SD (n = 3 mice). n.s (no significance) P > 0.05, *P < 0.05, **P < 0.01, and ***P < 0.001 by two-tailed Student’s t-test. Source data are provided as a Source Data file.