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. 2022 Nov 25;2:151. doi: 10.1038/s43856-022-00216-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — n = 229 study participants. Box indicates 25th, 50th, and 75th percentile absolute error, and whiskers indicate 5th and 95th percentile absolute error. Blue color refer to 3 months after two-dose vaccination, while orange color refer to 6 months. The detected positive rate and cell fraction of SARS-CoV-2-specific CD4⁺ T cell responses (OX40⁺ CD137⁺) (a) and the SARS-CoV-2-specific CD8⁺ T cell responses (CD69⁺ CD137⁺) (b) in different chronic diseases subgroups and healthy control, quantified by AIM assays.