Table 3.
Impact of PNN attenuation on reward seeking.
| Natural reward | Species/Sex | Age | Brain area | Treatment | Time relative to treatment | Behavior | Citation |
|---|---|---|---|---|---|---|---|
| Food: consumption | Mice/Male | Adult | Hypothalamus: median eminence | Ch-ABC injection and then monitored food intake | Food intake monitored for 6 days after Ch-ABC injection | ↑ in cumulative food intake and weight gain | Kohnke et al., 2021 |
| Food: CPP | Rats/Male | Adult | Amygdala: basolateral, central | Ch-ABC after food CPP training; Prior to morphine CPP extinction | 12 days | No effect on acquired food CPP | Xue et al., 2014 |
| Sucrose: 2 bottle choice | Mice/Male | Adult | Insular cortex | Ch-ABC prior to 2-bottle choice (sucrose, water) | 3 days | No change | Chen and Lasek, 2020 |
| Sucrose: CPP | Rats/Male | Adult | Hypothalamus: anterior dorsal lateral hypothalamus | Ch-ABC prior to CPP training | 3 days before training for CPP | No effect on acquisition of CPP or self-administration | Blacktop et al. 2017 |
| Sucrose: self-administration | Rats/Male | Adult | Hypothalamus: anterior dorsal lateral hypothalamus | Prior to self-administration training | 1 day before training for self-administration | No effect on acquisition of CPP or self-administration | Blacktop et al. 2017 |
| Sucrose: self-administration | Rats/Male | Adult | Hypothalamus: anterior dorsal lateral hypothalamus | Ch-ABC prior to cue reinstatement | 16 h | Trend towards reduced cue reinstatement | Blacktop and Sorg, 2019 |
| Drug reward | Species/Sex | Age | Brain area | Treatment | Time after treatment | Behavior | Citation |
| Cocaine | |||||||
| Cocaine: CPP (12 mg/kg train, 10 mg/kg test), IP | Rats/Male | Adult | Prefrontal cortex (PFC): Prelimbic | Ch-ABC prior to CPP training; Prior to extinction of CPP; Prior to memory retrieval | 3 days before acquisition; 1 day before extinction; 3 days before memory retrieval | Acquisition: ↓ Reconsolidation: ↓ | Slaker et al., 2015 |
| Cocaine: CPP (5 mg/kg train) | Mice/Male | Adult | Prefrontal cortex (PFC): Prelimbic Hippocampus: Dorsal | Brevican KO heterozygous | 1 day: No change; 21 days: ↓ incubation of CPP; rescued by brevican expression in dorsal hippocampus but not mPFC | Lubbers et al., 2016 | |
| Cocaine: CPP (10 mg/kg train), IP | Rats/Male | Adult | Hypothalamus: Anterior dorsal lateral | Ch-ABC prior to CPP | 3 days | Acquisition: ↓ | Blacktop et al. 2017 |
| Cocaine: CPP (10 mg/kg train, 5 mg/kg test), IP | Rats/Male | Adult | Amygdala: Basolateral amygdala (BLA) and central amygdala (CeA) | Ch-ABC prior to extinction of CPP | 12 days | Cocaine-primed reinstatement: ↓ | Xue et al., 2014 |
| Cocaine: self-administration (0.75 mg/kg/infusion train) IV; (5 mg/kg reinstatement), IP | Rats/Male | Adult | Amygdala: Basolateral amygdala (BLA) and central amygdala (CeA) | Ch-ABC prior to extinction of CPP | 15 days | Cocaine-primed reinstatement: ↓ | Xue et al., 2014 |
| Cocaine: self-administration (0.125 mg/kg/infusion), IV | Rats/Male | Adult | Hypothalamus: Anterior dorsal lateral | Ch-ABC prior to training | 1 day | Acquisition: ↓ Cue-induced reinstatement: ↓ | Blacktop et al. 2017 |
| Cocaine: self-administration (0.5 mg/kg/infusion), IV | Rats/Male | Adult | Hypothalamus: Anterior dorsal lateral | Ch-ABC prior to cue reinstatement | 16 h | Cue-induced reinstatement: ↓ | Blacktop and Sorg, 2019 |
| Ethanol | Species/Sex | Age | Brain area | Treatment | Time after treatment | Behavior | Citation |
| Ethanol 2-bottle choice | Mice/Male | 8 weeks |
Insular cortex Motor cortex |
Ch-ABC prior to 2-bottle choice drinking over 24 h | 3 days | Insular cortex: ↑ sensitivity to quinine-induced aversion to EtOH | Chen and Lasek, 2020 |
| OPIOIDS | Species/Sex | Age | Brain area | Treatment | Time after treatment | Behavior | Citation |
| Morphine CPP (10 mg/kg train, 30 mg/kg test), SC | Rats/Male | Adult | Amygdala: Basolateral amygdala (BLA) and central amygdala (CeA) | Ch-ABC prior to extinction of CPP | 12 days (reinstatement); 10 days (retention); 4 days (reconsolidation) | Morphine-primed reinstatement of CPP: ↓ No effect on retrieval, reconsolidation, or retention | Xue et al., 2014 |
| Heroin self-administration (0.05 mg/kg/infusion train) IV; 0.25 mg/kg reinstatement) SC | Rats/Male | Adult | Amygdala: Basolateral amygdala (BLA) and central amygdala (CeA) | Ch-ABC prior to extinction of CPP | 13 days (reinstatement); 40 days (spontaneous recovery) | Heroin-primed reinstatement of self-administration: ↓ Spontaneous recovery: ↓ | Xue et al., 2014 |