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. 2022 Nov 24;13(11):994. doi: 10.1038/s41419-022-05411-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A–C Graphs report the mRNA expression levels by RT-qPCR of the immune checkpoints Ctla4 and its ligands Cd80 and Cd81 (A), Lag3 (B), Icos and its ligand Icosl (C). D Heatmap representing the mRNA levels of genes of interest (indicated on the top) expressed as Log₂FC (TPM + 1) in different tumours from murine HCC models obtained by hydrodynamically injecting plasmids to overexpress MYC in combination with different oncogenes (indicated on the left), compared with control livers. Results were extracted from a publicly available database with the GEO accession number GSE148379.