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. 2022 Nov 25;13(11):996. doi: 10.1038/s41419-022-05445-w

Fig. 5. Exogenous TSG-6 ameliorated murine psoriasis-like inflammation.

Fig. 5

The psoriatic mice were injected subcutaneously with 7 µg rhTSG-6 dissolved with 150 µL PBS or 150 µL PBS alone on days 1 and 4 (n = 5 mice for each group). A The experimental scheme. B, C rhTSG-6 impaired neutrophil accumulation in spleen and skin of IMQ-induced psoriatic mice; enumeration of neutrophil frequency in skin and spleen. D The Ly6G immunostaining of skin in both groups; enumeration of Ly6G positive cells. E H&E staining of lesions; measurement of epidermal thickness. F The Ki-67 immunostaining of skin in both groups; enumeration of Ki-67 positive cells. G PASI scores of psoriatic mice in the indicated groups at all time points. Scale bars: 50 µm. Data were shown as means ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.