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. 2022 Nov 24;13:7216. doi: 10.1038/s41467-022-34865-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Correlations (Pearson) of the used diagnostic findings with each other. (a) Relationships between the two CT features (maximum CT-contrast-enhanced gut wall thickness and maximum signal density of the gut wall, n = 32, r = 0.6673, 95% CI = 0.4153–0.8242, r² = 0.4453 and two-tailed P < 0.0001). b Correlations between two MRI features (MRI-contrast-enhanced gut wall thickness and normalized T1 signal, n = 40, r = 0.4977, 95% CI = 0.2204–0.7006, r² = 0.2477 and two-tailed P = 0.0011). c Correlations between the CT feature (CT-contrast-enhanced gut wall thickness) and the MRI feature (MRI-contrast-enhanced gut wall thickness), n = 25, r = 0.457, 95% CI = 0.07551–0.7218, r² = 0.2089 and two-tailed P = 0.0216. d Correlations between the CT feature (CT-contrast-enhanced gut wall thickness) and the PET feature (PUVmaxn), n = 28, r = −0.4497, 95% CI = −0.7046 to −0.0924, r² = 0.2022 and two-tailed P = 0.0164. e Correlations between the PET feature PUV_maxn (maximum standard uptake value) and the MRI features (MRI-contrast-enhanced gut wall thickness), n = 13, r = −0.8205, 95% CI = −0.9445–0492, r² = 0.6733 and two- tailed P = 0.0006. Temporal development of the colitis-like phenotype in M. sexta at baseline conditions and after Bt treatment after 3 h, 12 h, and 24 h or 36 h in f PET, n = 63, one-way ANOVA, F(3,59) = 6.064, R² = 0.2357, P = 0.0011, box plots: 25th–75th percentiles, whiskers: min–max (show all points), center: median, g and i CT, n = 56, Kruskal-Wallis test = 32.54, P < 0.0001 and n = 38, one-way ANOVA, F(2,35) = 35.66, R² = 0.6708, P < 0.0001, and h, j, and l MRI, n = 78, one-way ANOVA, F(2,75) = 46.52, R² = 0.5537, P < 0.0001, n = 51, Kruskal-Wallis test = 38.45, P < 0.0001 and n = 49, Kruskal-Wallis test = 17.36, P = 0.0002. The following significance levels have been used: ns = P > 0.05, * = P ≤ 0.05, ** P ≤ 0.01, *** = P ≤ 0.001 and **** = P ≤ 0.0001. The dashed lines in the diagrams illustrate the respective threshold values received from the ROC analysis. Error bars represent standard deviation. Bar charts represent mean and SD. Every data point represents a single animal. Source data are provided as a Source Data file.