Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 24;13:7216. doi: 10.1038/s41467-022-34865-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Comparative structures of DUOX in M. sexta and Homo sapiens (DUOX2). b Homology modeling of M. sexta DUOX. The known structure of H. sapiens DUOX1 (left) and model-assisted protein binding site prediction of M. sexta DUOX (right). Regions that were not modeled in the human DUOX1 template structure are also not shown in the model of M. sexta DUOX. c The peroxidase homology domain (PHD) is the active site of HOCl production and is predicted to be highly conserved by model-assisted protein binding site prediction. d DUOX-dependent HOCl production after uracil treatment and its inhibition with diphenyleneiodonium (DPI) but not with N-acetylcysteine (NAC), n = 16, two-tailed t test. Bar charts represent mean and SD. Every data point represents a single animal. Source data are provided as a Source Data file. n = 30, one-way ANOVA, F(3,26) = 3.084, R² = 0.2624, P = 0.0448. Bar charts represent mean and SD. Every data point represents a single animal. Source data are provided as a Source Data file.