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. 2022 Nov 24;13:7216. doi: 10.1038/s41467-022-34865-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a–c High-throughput CT, MRI, and FDG-PET reveal an uracil-induced colitis-like phenotype, which is ameliorated by the DUOX inhibitor diphenyleneiodonium (DPI) or the ROS scavenger N-acetylcysteine (NAC), a1: n = 85, one-way ANOVA, F(3,81) = 23.77, R² = 0.4682, P < 0.0001, a2: n = 79, one-way ANOVA, F(3,875) = 14.6, R² = 0.3687, P < 0.0001, b1: n = 107, one-way ANOVA, F(3,103) = 16.45, R² = 0.3239, P < 0.0001, b2: n = 80, one-way ANOVA, F(3,76) = 4.016, R² = 0.1368, P = 0.0104 and c1: n = 75, one-way ANOVA, F(3,71) = 9.627, R² = 0.2892, P < 0.0001. a3, b3, and e Concentration-dependent effect of DUOX (activated by uracil) and successive worsening of the colitis-like phenotype a3: n = 44, one-way ANOVA, F(2,41) = 16.48, R² = 0.4457, P < 0.0001, b3: n = 67, one-way ANOVA, F(2,64) = 6.809, R² = 0.1755, P = 0.0136 and E: n = 66, one-way ANOVA, F(2,63) = 5.014, R² = 0.1373, P = 0.0095. d Mean sequential CT gut wall thickness curves (the horizontal lines represent the overall treatment-specific mean thickness), preferred model: different curve for each data set, F(6, 535) = 330.2, P < 0.0001). f, f1 CT imaging revealed the rescue of the uracil-induced phenotype by dexamethasone (Dex) treatment, n = 31, one-way ANOVA, F(2,28) = 41.71, R² = 0.7487, P < 0.0001. Dashed lines indicate threshold values. Significance levels: ns = P > 0.05, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 and ****P ≤ 0.0001. Bar charts represent mean and SD. Every data point represents a single animal. Box plots represent 25th–75th percentiles; whiskers represent min-max (show all points), and the centers represent median values. Source data are provided as a Source Data file.