Table 2.
Baseline characteristics of the patient cohort
| Total n = 7,890 | Adults n = 6,148 | Pediatric n = 1,742 | |
|---|---|---|---|
| Demographic characteristics | |||
| Age, years | |||
| Mean (SD) | 45 (26) | 56 (17) | 6 (5) |
| Median (IQR) | 51 (24,66) | 58 (43,69) | 4 (1,9) |
| Sex, n (%) | |||
| Females, n (%) | 4,053 (51.4%) | 3,242 (52.7%) | 811 (46.6%) |
| Residence, n (%) | |||
| Urban | 6,697 (84.9%) | 5,187 (84.4%) | 1,510 (86.7%) |
| Northern Alberta | 3,960 (50.2%) | 3,295 (53.6%) | 665 (38.2%) |
| Southern Alberta | 3,930 (49.8%) | 2,853 (46.4%) | 1,077 (61.8%) |
| Clinical characteristics | |||
| Charlson Comorbidity Index | |||
| Score, mean (SD) | 1.6 (2.2) | 1.8 (2.3) | 0.7 (1.7) |
| Comorbidities within the index, n (%) | |||
| Cancer | 1,307 (16.6%) | 1,145 (18.6%) | 162 (9.3%) |
| Chronic pulmonary disease | 1,208 (15.3%) | 1,106 (18.0%) | 102 (5.9%) |
| Diabetes | 1,169 (14.8%) | 1,140 (18.5%) | 29 (1.7%) |
| Rheumatoid disease | 694 (8.8%) | 647 (10.5%) | 47 (2.7%) |
| Renal disease | 606 (7.7%) | 557 (9.1%) | 49 (2.8%) |
| Heart failure | 514 (6.5%) | 480 (7.8%) | 34 (2.0%) |
| Liver disease | 392 (5.0%) | 335 (5.5%) | 57 (3.2%) |
| Cerebrovascular disease | 378 (4.8%) | 335 (5.5%) | 43 (2.5%) |
| Myocardial infarction | 252 (3.2%) | > 243 (> 4.0%) | < 10 |
| Metastatic cancer | 252 (3.2%) | 200 (3.3%) | 52 (3.0%) |
| Peripheral vascular disease | 210 (2.7%) | 184 (3.0%) | 26 (1.5%) |
| Hemiplegia or paraplegia | 168 (2.1%) | 110 (1.8%) | 58 (3.3%) |
| Peptic ulcer | 148 (1.9%) | > 139 (> 2.3%) | < 10 |
| Dementia | 76 (1.0%) | 76 (1.2%) | N/A |
| Primary or secondary immunodeficiency, n (%) | 1,872 (23.7%) | 1,692 (27.5%) | 180 (10.3%) |
| IgG administration on the index date, n (%) | |||
| IVIg | 7,547 (95.7%) | 5,819 (94.7%) | 1,728 (99.2%) |
| SCIg | 343 (4.3%) | 329 (5.3%) | 14 (0.8%) |
| Self-administered | > 334 (> 4.2%) | > 320 (> 5.2%) | > 10 (> 0.6%) |
| Clinic-administered | < 10 | < 10 | < 10 |
IQR interquartile range; IVIg intravenous immunoglobulin G; SCIg subcutaneous immunoglobulin G; SD standard deviation