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. 2022 Nov 25;22:193. doi: 10.1186/s12894-022-01151-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The effects of enforced NEAT1 on tumour growth and metastasis of BC. A The tumour implant was established as an orthotopic bladder cancer model, leading to tumorigenicity in vivo (the bladder model is marked by the red arrow). B The bladder weight of mice was significantly increased in the NEAT1 group; **p < 0.05 NEAT1 group versus CON and NC groups. C–H Histopathological cell morphology of the bladder, liver, lung, kidney, stomach and heart tissues was examined by H&E staining (magnification, × 200). Bladder cancer cells showed high-grade dysplasia, disorder, hyperchromatic nuclei and nuclear division in bladder tissues in all groups (the cancer cell is marked by the black arrow). Liver metastasis occurred only in the NEAT1 group, as indicated by necrosis of large numbers of hepatocytes and infiltration of cancer cells (the metastatic foci is marked by the black arrow). No metastatic lesions were detected in the lung, kidney, stomach and heart, in the three groups