Fig. 5.

The expression of NEAT1, miR-101 and VEGF-C in an orthotopic bladder cancer model. A The results of immunohistochemical staining showed that VEGF-C expression was significantly increased in the NEAT1 group (the immunohistochemical positive cell is marked by the black arrow), **p < 0.01. NEAT1 group versus CON and NC groups (magnification × 200). B The expression of NEAT1 and VEGF-C mRNAs were significantly increased after NEAT1 transfection. *p < 0.05, **p < 0.01 NEAT1 group versus CON and NC groups. The expression of miR-101 mRNA was significantly decreased after NEAT1 transfection. *p < 0.05, **p < 0.01 NEAT1 group versus CON and NC groups. C The expression of VEGF-C protein was significantly increased after NEAT1 transfection (Additional file 4: Figure S4). *p < 0.05, **p < 0.01 NEAT1 group versus CON and NC groups