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. 2022 Nov 24;20:187. doi: 10.1186/s12964-022-00989-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Efflux capacity of BRAF^V600E mutant MaMel cells. A Representative scatter plots of the side population (SP) assay detecting the efflux of DyeCycle Violet stain (DCV) in MaMel cells. The polygonal gates indicate the SP subsets (DCV-) for each cell line. B Quantification of the percentage of SP cells. C Heatmap displaying the normalized expression (z-score) of genes encoding for ABC transporter family members. D Representative scatter plots of the SP assay for MaMel21 after inhibition of ABC transporters with verapamil, Ko143, or the combination, in comparison to DMSO control. The polygonal gates indicate the SP subsets for each condition. E Quantification of the percentage of SP cells. All bar plots show the mean ± SD of three independent experiments (n = 3). *p < 0.05, **p < 0.01, ****p < 0.0001