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. 2022 Nov 24;27:104. doi: 10.1186/s11658-022-00405-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Significant decline in enzymatic activity in HA patients’ (RK and MK) erythrocytes hemolysate caused by lack of cytosolic pyrimidine 5′-nucleotidase. The results for RK and MK are statistically significant at p < 0.001 in relation to asymptomatic family members (EK, AK) (for all family members we used technical replicates) and the control group (for four healthy individuals we used biological and technical replicates). Student’s t-test, ***p < 0.001. Error bars represent standard deviation