Table 2.
The differential metabolites in lung tissue of mice
| NO. | Metabolites | Formula | Rt (min) | M/Z | VIP | Con vs. LPS | LPS vs.DM-M | LPS vs.DM-H | Fragmentations (m/z) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P | FC | P | FC | P | FC | |||||||
| 1 | Ergothioneine | C9H15N3O2S | 0.94 | 230.0975 | 6.85519 | 8.89E-06 | 5.223586 | 0.028336 | 0.722204 | 0.000399 | 0.484999 | 69.0580; 127.0362 |
| 2 | ( +)-Gallocatechin | C15H14O7 | 1.07 | 307.0829 | 5.01184 | 3.85E-14 | 1.539765 | 2.77E-09 | 0.776547 | 9.53E-09 | 0.573716 | 139.0390; 307.08113 |
| 3 | Oxidized glutathione | C20H32N6O12S2 | 1.08 | 635.142 | 1.24098 | 0.001474 | 1.349826 | 0.063388 | 0.857859 | 1.44E-05 | 0.603938 | 355.0759; 484.1187 |
| 4 | Inosinic acid | C10H13N4O8P | 0.97 | 349.056 | 3.46688 | 1.50E-06 | 2.506744 | 0.06727 | 0.82939 | 1.75E-06 | 0.426869 | 97.0298; 137.0457 |
| 5 | Guanosine monophosphate | C10H14N5O8P | 0.95 | 364.0649 | 3.05321 | 0.00017 | 1.608101 | 0.084982 | 0.856493 | 4.66E-06 | 0.533426 | 152.0562 |
| 6 | S-Adenosylhomocysteine | C14H20N6O5S | 1.05 | 385.1303 | 2.64985 | 2.61E-05 | 1.629015 | 0.016513 | 0.811106 | 0.00022 | 0.686493 | 112.0183; 170.0849 |
| 7 | all-trans-5,6-Epoxyretinoic acid | C20H28O3 | 13.52 | 317.2117 | 2.30797 | 0.000264 | 1.933585 | 0.045855 | 0.778557 | 0.000488 | 0.550082 | 79.0542; 281.1900 |
| 8 | Creatine | C4H9N3O2 | 0.91 | 132.0775 | 1.79766 | 6.98E-05 | 1.485564 | 0.002392 | 0.766444 | 5.19E-06 | 0.595529 | 44.1000; 55.2000 |
| 9 | LysoPC(17:0/0:0) | C25H52NO7P | 18.32 | 527.3804 | 1.36725 | 7.89E-06 | 3.681324 | 0.018519 | 0.721019 | 0.000698 | 0.545856 | 184.0733; 492.3449 |
| 10 | Pyridoxamine | C8H12N2O2 | 0.78 | 191.0781 | 1.1411 | 1.63E-06 | 1.624016 | 3.72E-06 | 0.662852 | 5.36E-07 | 0.599696 | 134.0606; 151.0871 |
| 11 | Spermidine | C7H19N3 | 0.72 | 146.1654 | 1.13866 | 1.21E-05 | 1.445056 | 0.007625 | 0.818006 | 2.44E-06 | 0.659883 | 72.0820; 84.0840 |
| 12 | L-Proline | C5H9NO2 | 0.91 | 116.0703 | 1.06339 | 3.29E-06 | 1.593842 | 4.40E-05 | 0.70307 | 3.14E-06 | 0.605171 | 70.0651; 41.0386 |
| 13 | Spermine | C10H26N4 | 13.76 | 241.18 | 1.05343 | 4.59E-05 | 2.891314 | 0.077649 | 0.785466 | 8.89E-05 | 0.389801 | 58.0657; 186.1970 |
| 14 | 4-Hydroxyphenylpyruvic acid | C9H8O4 | 3.68 | 181.0491 | 1.19548 | 0.000492 | 2.762776 | 0.011312 | 0.58101 | 0.000701 | 0.392195 | 77.0391; 107.0497 |
| 15 | Diaminopimelic acid | C7H14N2O4 | 0.79 | 213.0852 | 1.8311 | 1.40E-09 | 2.180373 | 9.35E-06 | 0.565259 | 7.44E-10 | 0.411171 | 82.0652; 128.0705 |
| 16 | LysoPC(P-16:0/0:0) | C24H50NO6P | 19 | 480.3413 | 1.87704 | 1.64E-06 | 0.514088 | 0.003854 | 1.339187 | 3.65E-06 | 1.649673 | 180.0188; 462.3343 |
| 17 | Leukotriene C4 | C30H47N3O9S | 12.14 | 626.3128 | 1.31377 | 7.35E-08 | 0.286374 | 0.024872 | 1.351636 | 3.93E-07 | 2.82934 | 189.1638; 319.2268 |
| 18 | LysoPE(0:0/18:2(9Z,12Z)) | C23H44NO7P | 16.79 | 478.2935 | 1.615482 | 0.002276 | 1.730487 | 0.000351 | 0.530287 | 2.76E-05 | 0.393158 | 263.2369; 337.2737 |
| 19 | PGP(18:0/18:2(9Z,12Z)) | C42H80O13P2 | 29.14 | 872.5415 | 1.854269 | 3.27E-06 | 2.225789 | 0.000646 | 0.628777 | 1.16E-06 | 0.394302 | 603.5347; 757.5378 |
| 20 | Anileridine | C22H28N2O2 | 18.7 | 353.2236 | 1.5043 | 4.90E-07 | 2.232817 | 0.004675 | 0.783746 | 1.08E-05 | 0.600209 | 120.0808; 279.1856 |
| 21 | 4-Oxoretinal | C20H26O2 | 13.32 | 299.2014 | 1.25101 | 0.000157 | 1.724575 | 0.008411 | 0.73029 | 3.73E-06 | 0.487338 | 137.0961; 189.1274 |
| 22 | LysoPE(0:0/20:0) | C25H52NO7P | 19.76 | 510.3511 | 2.43664 | 9.46E-09 | 0.428477 | 0.000292 | 1.721601 | 4.79E-07 | 2.180142 | 44.0495; 369.3363 |
| 23 | LysoPE(0:0/22:0) | C27H56NO7P | 23.79 | 538.3835 | 1.752036 | 0.000226 | 0.435181 | 0.009919 | 1.432045 | 3.59E-06 | 2.272196 | 44.0495; 397.3676 |
| 24 | LysoPG(16:0/0:0) | C22H45O9P | 21.28 | 483.2727 | 4.0505 | 0.000257 | 0.438891 | 2.68E-05 | 1.515575 | 2.20E-08 | 2.256267 | 483.2728 |
| 25 | Cholic acid | C24H40O5 | 13.08 | 407.2826 | 2.24678 | 1.49E-14 | 0.315424 | 2.92E-09 | 2.107035 | 3.85E-10 | 3.146423 | 345.2794; 373.2743 |
| 26 | Prostaglandin A2 | C20H30O4 | 14.39 | 333.2069 | 1.57342 | 1.37E-11 | 0.391936 | 0.004173 | 1.707462 | 4.52E-06 | 2.156729 | 67.0542; 299.2006 |