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. 2022 Nov 24;22:443. doi: 10.1186/s12890-022-02209-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Circ_0017109 promotes FZD4 expression via sponging miR-671-5p. A miR-671-5p target sequence in the FZD4 3′-UTR was predicted using Targetscan database. B Luciferase activity of wild type or mutated FZD4 reporter in the presence of miR-NC or miR-671-5p mimic. C FZD4 mRNA and protein expression in H1229 and A549 cells after the transfection of miR-671-5p mimic. D The effect of circ_0017109 silencing and miR-671-5p inhibitor on FZD4 protein level. E Relative FZD4 expression in NSCLC tumor and normal lung tissue samples. F Relative miR-671-5p levels in NSCLC tumor and normal lung tissue samples. G Correlation of FZD4 expression and miR-671-5p in NSCLC tumor samples. H FZD4 level and circ_0017109 expression in NSCLC tumor samples. ***, P < 0.001 compared with si-NC group, and ^^^, P < 0.001 compared with si-circ_0017109 group