Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 25;3(11):1300–1317. doi: 10.1038/s43018-022-00450-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022, corrected publication 2022, 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a, Diagram of the steps involved in a successful T cell-mediated anti-tumor response: (1) Initial TIL infiltration, antigen presentation and clonal expansion. (2) Antigen presentation in the lymph nodes and activation/replication of T cells. (3) Clonal expansion and T cell activation in the blood post-treatment. (4) Immune suppression by T_reg cells in the TME after treatment. b, Summary of each patient who failed therapy compared with the average responder. No evidence of a step in a patient is depicted with ‘−’, some evidence of a step is indicated with ‘+’ and a lot of evidence of a step is indicated with ‘++’. TDLN, tumor draining lymph node.