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. 2022 Nov 25;3(11):1300–1317. doi: 10.1038/s43018-022-00450-6

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© The Author(s) 2022, corrected publication 2022, 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — (A) Representative image of volumetric contouring of gross tumor only to determine the specific doses of SBRT delivered. (B) A multiple logistic regression analysis was used to determine if time to surgery or dose of radiation can independently account for pathological response at time of surgery (n = 19 patients). P = 0.07 (coefficient estimate per Gy of RT = 0.2253, s.e.m. = 0.1429, CI (−0.03648,0.5582); intercept for the logistic regression was −6.207). (C) Representative MRI of a patient pre- and post-treatment with tumor volume measurements magnified. (D) Representative CT image of a patient pre- and post-treatment with tumor volume measurements magnified. (E) White blood cell (WBC) count for each patient at four time points (C1D1, surgery, end of treatment (EOT) and 6-month follow-up). C1D1 n = 21 patients, surgery n = 20 patients, EOT n = 12 patients and 6-month follow-up n = 8 patients (P = 0.0006*** and P = 0.0019**). A multiple linear regression test was used to determine interdependence of time to surgery and dose of radiation for B. Statistical significance was determined by a paired two-sided Student’s t-test for E. Significance was concluded if P<0.05 (*P<0.05, **P<0.01, ***P<0.001). These are representative images of 21 patients.