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. 2022 Nov 7;3(11):1367–1385. doi: 10.1038/s43018-022-00443-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — (A) GSEA enrichment scores (NES) of type I IFN signaling in mouse ΔS and human 9pS tumors compared to ΔL and 9pL tumors, respectively. (B) Comparison of GSEA NES scores for Reactome Pathways enriched in mouse ΔS (y axis) and human 9pS tumors (x axis). Highlighted are key pathways and immune populations enriched in IFN-proficient tumors. Circle size represents the adjusted p value (the scale is shown in panel C). Patient data is from primary tumors (9pS n = 37 patients and 9pL n = 28 patients). (C) Comparison of GSEA NES scores and Immune populations enriched in mouse ΔS (y axis) and human 9pS tumors (x axis). Highlighted are key immune populations enriched in IFN-proficient tumors. Circle size represents -log(adjusted p value). Patient data is from primary tumors (9pS n = 37 patients and 9pL n = 28 patients). (D) GSEA enrichment scores (NES) of type I IFN signaling in human primary (1ary) or metastatic (Mets) 9pS tumors compared to 9pL tumors from the COMPASS and TCGA datasets. (E) Hallmark pathways downregulated in human PDAC liver metastases vs. primary tumors. Data from Moffitt et al., 2015⁷².