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. 2022 Nov 26;2:152. doi: 10.1038/s43856-022-00213-5

Fig. 2. The TP17/86 cocktail delays SARS-CoV-2 infection in huACE2 Tg mice.

Fig. 2

a Overview of the experiment design. Lethal dose of SARS-CoV-2 (ancestral strain and Delta, 1 × 104 TCID50; Omicron, 1 × 105 TCID50) was intratracheally (i.t.) inoculated to six mice (3 male and 3 females) and followed by the administration of the TP17/86 cocktail (dark colors) or vehicle (bright colors) at dpi 1. The TP17/86 cocktail suppressed body weight loss and prolonged survival of the mice infected with ancestral strain (b), Delta (c), and Omicron BA.1 (d). e Subgenomic RNA levels of SARS-CoV-2 Tokyo strain at dpi 3. Data are represented as the average and ± SD (n = 5).