TABLE 1.
Minimal lethal concentrations of cationic peptides needed to inhibit the growth of various Brucella strains in agar plates
| Peptide | Minimum lethal concn (μg/ml)
|
||
|---|---|---|---|
| B. abortus S19 | B. abortus 45/20 | B. ovis REO 198 | |
| Bactenecin 7 | 4.25 ± 1.08 | 0.72 ± 0.02 | 0.45 ± 0.06a |
| Bactenecin 5 | 24.37 ± 2.57 | 4.05 ± 0.48 | 0.07 ± 0.00a |
| Polymyxin B | 0.36 ± 0.02 | 0.13 ± 0.01 | 0.12 ± 0.01 |
| Lactoferricin B | >95 | 43.72 ± 2.14 | 1.63 ± 0.18a |
| Cationic protein 18A | 2.85 ± 0.07 | 1.40 ± 0.06 | 1.18 ± 0.03b |
| Melittin | 1.67 ± 0.12 | 1.56 ± 0.19 | 1.05 ± 0.11b |
| Poly-l-lysine | >95 | 23.67 ± 0.23 | 12.69 ± 2.45a |
| Poly-l-ornithine | >95 | 90.03 ± 0.82 | 66.17 ± 14.83c |
a
Significantly different from the results obtained with B. abortus 45/20 (P < 0.001).
b
Significantly different from the results obtained with B. abortus 45/20 (P < 0.02).
c
Significantly different from the results obtained with B. abortus 45/20 (P < 0.01).