TABLE 1.
Baseline characteristics of patients with UDCA‐refractory cirrhotic primary biliary cholangitis
| Characteristic | FF group | UDCA group | p value |
|---|---|---|---|
| n = 32 | n = 27 | ||
| Age, years (mean ± SD) | 54 ± 10 | 55 ± 7 | p = 0.671 |
| Female, n (%) | 28 (88) | 25 (93) | p = 0.678 |
| Follow‐up time, months | 36 (24–48) | 36 (24–60) | p = 0.895 |
| AMA positive, n (%) | 28 (87) | 23 (85) | p = 1.000 |
| Child‐Pugh A/B, n (%) | 27 (85)/5 (15) | 23 (86)/4 (14) | p = 1.000 |
| MELD score | 8.0 (7.0–10.0) | 8.0 (7.0–9.0) | p = 0.658 |
| APRI index | 1.6 (1.0–2.6) | 1.8 (1.3–2.8) | p = 0.263 |
| ALP × ULN | 2.6 (2.0–3.0) | 2.2 (1.9–3.0) | p = 0.479 |
| GGT × ULN | 6.7 (4.1–12.2) | 3.6 (2.5–5.6) | p = 0.001 |
| ALT × ULN | 1.6 (1.1–2.0) | 1.2 (0.9–1.9) | p = 0.105 |
| AST × ULN | 1.7 (1.4–2.4) | 1.9 (1.3–2.6) | p = 0.939 |
| ALB × LLN | 1.0 (0.9–1.1) | 1.0 (0.9–1.1) | p = 0.558 |
| Tbil × ULN | 1.1 (0.8–1.6) | 1.0 (0.8–1.5) | p = 0.744 |
| PLT (×109/L) | 118 (78–161) | 91 (76–100) | p = 0.115 |
| IgG × ULN | 0.8 (0.7–0.9) | 1.0 (0.9–1.1) | p = 0.001 |
| IgM × ULN | 1.3 (0.8–1.7) | 1.0 (0.8–1.6) | p = 0.760 |
| TG × LLN | 0.9 (0.7–1.5) | 0.6 (0.5–0.7) | p < 0.001 |
| BU × ULN | 0.6 (0.5–0.7) | 0.7 (0.5–0.8) | p = 0.188 |
| Scr × ULN | 1.0 (0.8–1.1) | 0.9 (0.8–1.0) | p = 0.891 |
| eGFR (ml/minute/1.73 m2) | 96 (91–101) | 95 (87–103) | p = 0.692 |
Note: Shown are the median values and interquartile ranges.
Abbreviations: ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AMA, anti‐mitochondrial antibody; APRI, aspartate aminotransferase‐to‐platelet ratio index; AST, aspartate aminotransferase; BU, blood urea; eGFR, estimated glomerular filtration rate; FF, fenofibrate; GGT, gamma‐glutamyl transpeptidase; IgG, immunoglobulin G; IgM, immunoglobulin M; LLN, lower limit of normal; MELD, Model for End‐Stage Liver Disease; PLT, platelet; Scr, serum creatinine; Tbil, total bilirubin; TG, triglyceride; UDCA, ursodeoxycholic acid; ULN, upper limit of normal.