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. 2022 Oct 4;6(12):3550–3562. doi: 10.1002/hep4.2106

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© 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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DEN‐induced tumors are significantly reduced in Zhx2 ^Δliv mice compared with Zhx2 ^fl littermate controls. (A) Representative livers from Zhx2 ^fl and Zhx2 ^Δliv mice 9 months after DEN treatment. (B) Liver tumor number (left panel), maximal tumor size (middle panel), and liver/body weight ratio (right panel) of Zhx2 ^fl (n = 7) and Zhx2 ^Δliv (n = 9) mice 9 months after DEN treatment. ***p < 0.001 and ****p < 0.0001.